Starting from benzocaine, a well-known anaesthetic, ten derivatives were synthesized and characterized by uv–vis, ir, nmr, and elemental analysis most of the compounds contain residues with recognized biological activity, like nicotinic acid (vitamin b3 or pp), biotin (vitamin b7 or h), lipoic acid (thioctic acid). Exp't 86 the preparation of the local anesthetic, benzocaine, by an esterification reaction adapted by r minard (penn state univ) from introduction to organic laboratory techniques: a microscale approach pavia, lampman, kriz & engel, 1989 revised 10/18/06 introduction – local anesthetics local anesthetics, or. Benzocaine (2 steps synthesis) step 1 4-aminobenzoic acid reagents: 4- nitrobenzoic acid 2,1 g 12% nh4oh 15 ml 25% nh4oh 20 ml feso4x7h2o 44,6 g citric acid etyl acetate ch2cl2 instrumentation and glassware: erlenmayer flask 250 ml round-bottom flask 250 ml filtering flask with büchner funnel. Advanced search publication cover journal organic preparations and procedures international the new journal for organic synthesis volume 13, 1981 - issue 6 · journal homepage 28 views 1 crossref citations 0 altmetric oppi briefs one-pot process for benzocaine from p- nitrobenzoic acid. Using 95 % ethanol would reduce the yield of benzocaine.
Synthesis of benzocaine - download as word doc (doc), pdf file (pdf), text file (txt) or read online sintesis benzokain organik polifungsi. They are used in numerous the mechanism of the fischer esterification that was utilized to produce benzocaine is verystraightforward carbonyl chemis the purpose of this lab is to synthesize benzocaine, an ester, from p- 6484 ppm doublet 27568 ppm doublet benzocaine product would depress the. 3 step synthesis of benzocaine zoe a peterson st catherine university jordyn wentland st catherine university follow this and additional works at: http://sophiastkateedu/undergraduate_research_symposium this event is brought to you for free and open access by the conferences and events at sophia.
Synthesis, the synthesis of benzocaine is carried out by the acid-catalyzed esterification of 4-aminobenzoic acid with ethanol: the synthesis of benzocaine in a 5-ml round bottom flask, add 120 mg of 4-aminobenzoic acid (often called paba for paminobenzoic acid), 15 ml of absolute ethanol. Benzocaine is a local anesthetic, even though it is legal substance and can be purchased legally as a medication it found its way in criminal activity, therefore production of benzocaine may attract some interest from the authorities in any case, a small scale synthesis for the educational purpose should not be a problem. Synthesis of benzocaine purpose: to prepare benzocaine (a local anesthetic) from p-aminobenzoic acid and ethanol, via a fischer esterification reaction note: the ethanol used was denatured, and contained about 90% ethanol by weight experimental: 1)1002 g paba (07306 moles) were placed into a.
Sigma-aldrich offers sigma-aldrich-b7150, benzocaine solution for your research needs find product specific information including cas, msds, protocols and references. How to prepare benzocaine (fischer esterification) benzocaine is a local anesthetic commonly used for pain relief preparing benzocaine is often done in a school lab setting to demonstrate the acid-catalyzed esterification of a carboxylic. We perform a two-step synthesis in one video starting with p-nitrobenzoic acid to make benzocaine, a local anaesthetic we first esterify the starting compou.
Preparation of benzocaine, a local anesthetic p l k e, experiments in organic chemistry p 339 - 345 andrew aspaas and levi stanley 20 january, 2000 introduction: naturally occuring local anesthetics have been used for over a century to dull or alleviate the pain involved with medical procedures specifically , the. Synthesis of benzocaine 3 synthesis of acetylsalicylic acid 4 separation of the components of a painkiller tablet assessment: the mark obtained in the laboratory practicals represents 15% of the subject's final mark to pass the course it is necessary that students pass the laboratory practicals attendance at the six lab.