Since the onset of the new millennium the field of organocatalysis has undergone a great expansion led by investigations in the field of aminocatalysis this thesis will address some recent developments in aminocatalyzed cycloadditions and provide a theoretical background hereto cycloadditions were pioneered by otto. Phd thesis: “chiral organocatalysts mediated asymmetric oxyfunctionalization and tandem reactions” sara meninno dipartimento di chimica e biologia, università degli studi di salerno, via giovanni paolo ii, 132, 84084 fisciano ( sa) [email protected] abstract asymmetric organocatalysis is a new rapidly growing. Title: the direct β-activation of aldehydes and ketones via photoredox organocatalysis: discovery, scope, and mechanism this thesis details the discovery of a new activation mode that allows for the direct beta- functionalization of carbonyl species, such as aldehydes and ketones, through the synergistic merger of. Recent advancement in the area of asymmetric organocatalysis led to the development of new methodologies for the construction of valuable enantiopure molecules, including various heterocycles as one of the latter class of compounds tetrahydropyrans (thps) constitute a core structure of a wide array of. (thio)urea organocatalysis describes the utilization of properly designed derivatives of urea and thiourea to accelerate and stereochemically alter organic transformations predominantly through double hydrogen-bonding interactions with the respective substrate(s) (non-covalent organocatalysis) the scope of these. Keywords: organocatalysis(+)-trans-dihydrolycoricidinenatural product publication date: nov-2015 abstract: in the thesis, the development of asymmetric organocatalytic [3+3] sequences for the assembly of aminocyclitols is described a water-based wittig reaction was developed in order to produce the key enal-based.
In particular, this thesis describes the use of primary amine catalysts for highly enantioselective epoxidation of α-branched α,β-unsaturated aldehydes and for asymmetric α-benzoyloxylation of cyclic ketones and other carbonyl compounds apart from the obvious advantages of organocatalysis, such as the readily available. Recyclable organocatalysis of one-pot michael/mannich/lactamization sequence for asymmetric synthesis of fluorinated poly-substituted 2- piperidinones biochemistry honors thesis presented by anthony p tran research adviser: dr wei zhang. He carried out his doctoral studies under the supervision of dr declan gilheany and was awarded his phd for his thesis on metal(salen) chemistry in 2003 he then worked as a postdoctoral fellow in the group of dr gilheany, researching novel routes to p-stereogenic compounds since 2005, he has. Design, synthesis and evaluation of organocatalysts in 1,4-conjugate additions to nitroolefins and alkylidene malonates a thesis submitted to the national university of ireland in fulfilment of the requirements for the degree of doctor of philosophy by declan peter patrick gavin bsc (hons) department of chemistry.
Caruana lorenzo – doctoral thesis 13 12 asymmetric organocatalysis: the “ third pillar” of asymmetric synthesis the enantioselective synthesis of chiral compounds is still a primary issue for organic chemistry researchers most of organic compounds are chiral: from fragrances to agrochemicals, from amino acids to the. For full abstract, see thesis the present work deals primarily with the development of two new reactions in which scaffold 2 was reacted under organocatalytic conditionsn-heterocyclic carbenes and cinchona-based phase- transfer catalysts were both employed to promote elaboration of 1 we have shown that. Deakin university candidate declaration i certify the following about the thesis entitled “the synthesis and evaluation of novel, c2- symmetric organocatalysts”, submitted for the degree of “doctor of philosophy” a i am the creator of all or part of the whole work(s) (including content and layout.
Presented in this thesis is my effort on the development of michael addition- based cascade reaction sequences for the synthesis of fluorinated and other asymmetric molecules with biological interest organocatalysts, especially recyclable fluorous catalysts such as cinchona alkaloid/thiourea have been used for the. Is the tool used in this thesis different reaction mechanisms of several organocatalytic reactions have been examined, and we have been able to exclude various reaction pathways based on the calculated reaction barriers the origins of stereoselection in a number of reactions have been rationalized the computational. Mechanistic studies of azolium ions and their role in organocatalysis massey, richard,stephen (2013) mechanistic studies of azolium ions and their role in organocatalysis doctoral thesis, durham university.